Intra-articular injection of synovial mesenchymal stem cells improves cartilage repair in a mouse injury model.

Conditioned medium derived from mesenchymal Stem cells regenerates’ defected articular cartilage

Background & Aims: One of cell- based technical issues associated with cartilage repair assay is delivering cells to the site of the parts where damage is created. Mesenchymal stem cells (MSCs) with their chondrogenic potential are ideal candidates for cartilage regeneration. High expression of cartilage hypertrophy markers by MSCs would result in apoptosis and ossification. This investigation ...

The Effect of Mesenchymal Stem Cells and Aqueous Extract of Elaeagnus Angustifolia on the Mechanical Properties of Articular Cartilage in an Experimental Model of Rat Osteoarthritis

Introduction: Although, the effect of direct intra-articular injection of bone marrow stem cells (BMSCs) on the repair of articular cartilage and the effect of Elaeagnus angustifolia extract on pain relief in patients with osteoarthritis have been investigated, no studies has been conducted to compare the effects of these two therapeutic methods on the mechanical properties of articular cartila...

Articular Cartilage Regeneration Using Intra-articular Injection of Allogeneic Synovium-derived Mesenchymal Stem Cells in A Canine Model

Intra-Articular Injection of Synovium-Derived Mesenchymal Stem Cells with Hyaluronic Acid Can Repair Articular Cartilage Defects in a Canine Model

Objective: The purpose of this study was to evaluate effectiveness of intra-articular injection of synovium-derived mesenchymal stem cells (SMSCs) and hyaluronic acid (HA) for the treatment of articular cartilage defects in a canine model. Methods: Forty-eight knees of 24 beagle dogs were randomly assigned to 16 groups (n=3) according to both the number of injected SMSCs (0.5×105 cells, 5×106 c...

Clinically Translatable Cell Tracking and Quantification by MRI in Cartilage Repair Using Superparamagnetic Iron Oxides

BACKGROUND Articular cartilage has very limited intrinsic regenerative capacity, making cell-based therapy a tempting approach for cartilage repair. Cell tracking can be a major step towards unraveling and improving the repair process of these therapies. We studied superparamagnetic iron oxides (SPIO) for labeling human bone marrow-derived mesenchymal stem cells (hBMSCs) regarding effectivity, ...